Whichtests

Which tests confirm SCPCD?

Several laboratory tests are recommended upon signs of purpura fulminans:^1,2

Protein C (PC) activity assay

Protein S assay (low PC levels but normal Protein S levels are suggestive of SCPCD)

Protein C antigen

Platelets

Fibrinogen

D-dimer

Prothrombin time (PT)

Activated partial prothrombin time

Genetic analysis

Protein C level testing in parents (Protein C activity assay and Protein C antigen)

Given possible confounding factors, protein C deficiency should be confirmed using multiple methods²

To determine if the protein C deficiency is congenital, protein C activity assays in family members are recommended, if available, to determine if the genetic mutation is homozygous or heterozygous²

Treatment for SCPCD What is protein C deficiency?Discover more about SCPCD

References:

Goldenberg N, Manco-Johnson M. Protein C deficiency. Haemophilia. 2008;14(6):1214–1221.
Price VE, et al. Diagnosis and management of neonatal purpura fulminans. Semin Fetal Neonatal Med. 2011;16(6):318-22.

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