How to reconstitute CEPROTIN®
CEPROTIN® is administered by intravenous injection after reconstitution of the lyophilised powder for solution with sterilised water for injections.1*
How to dose CEPROTIN®CEPROTIN® manufacturing and safety
Treatment with CEPROTIN® should be initiated under the supervision of a physician experienced in substitution therapy with coagulation factors/inhibitors where monitoring of protein C activity is feasible1
How to reconstitute CEPROTIN®:
Reconstitute the CEPROTIN® (500 IU or 1000 IU powder) using the supplied solvent (sterilised water for injections) using a sterile transfer needle.
Gently rotate the vial until all of the powder is dissolved.
After reconstitution, the solution should be colourless to slightly yellowish and clear to slightly opalescent and free of visible particles.
Draw the solution through the sterile needle filter into a sterile disposable syringe.
The solution should be discared if any particulate matter is visible
The reconstitued solution should be administered immediately by intravenous or subcutaneous injection.
Any unused medicinal product or waste material should be disposed of in accordance with local requirements.
These images are for illustration only. In rare and exceptional cases, subcutaneous infusion of 250-350 IU/Kg was able to produce therapeutic protein C plasma levels in patients with no intravenous access.1
References:
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CEPROTIN. Summary of Product Characteristics (SmPC). EMA approved – last updated 09/2017.
*Based on EMA approved labelling for CEPROTIN.