What is protein C deficiency?

Protein C deficiency can be caused by mutation of the protein C gene (congenital protein C deficiency) or as a result of other conditions (acquired protein C deficiency).^1,2 The severity of the deficiency is determined by the remaining plasma activity of protein C.¹

Severe Congenital Protein C Deficiency is an autosomal recessive, rare disorder that leads to high initial mortality and long-term morbidity in survivors.^1,2 In neonates, SCPCD can manifest, as early as 2-12 hours after birth, as purpura fulminans with necrosis of the skin, disseminated intravascular coagulation, arterial and venous thrombosis.^1-3

Which tests confirm SCPCD?

The severity of protein C deficiency is based on protein C activity ¹